Thursday, October 31, 2019

Placebos - What They Are and How They Are Used in Clinical Trials




Dr. Hanid Audish serves as the principal investigator at Encompass Clinical Research. Based in Spring Valley, California, the company completes a range of clinical research projects relating to such things as diabetes, osteoarthritis, and low testosterone. For many of these studies, Dr. Hanid Audish and his team use placebos.

Also known as dummy pills, placebos are inactive substances that are administered via a capsule, tablet, or other method that is the same as the actual treatment. Usually, a placebo contains sugar, starch, or saline, but it does not contain any active medication. Since placebos are designed to look and taste like medication, without actually administering anything to patients, they are common parts of clinical trials. They serve as a control and help researchers better measure the effectiveness of the experimental drug or treatment being studied since placebos do not directly affect the illness.

Interestingly, about one-third of people receiving placebos report a change in their symptoms due to the “treatment.” This is referred to as the placebo effect. Usually, these reported changes last for a short time, but they can affect the idea of how effective new treatments are. For this reason, experimental drug results are usually compared to placebo results to determine if they are statistically significant or not.

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